Research and Activity Reports Research Publications
Research Publications
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■■2023■■
【The 14th Annual meeting of Asian Cellular Therapy Organization】
Comparative analysis of islets derived from patients with type 2 diabetes and healthy individuals using clinically optimized multi-omics analysis will be enhanced by information obtained from induced pluripotent stem cell (iPSC) generation techniques and perfusion assays.
Yoshiki N , Tsukahara M Yoshiki Nakashima, a research scientist at the CiRA Foundation, was selected as one of the 5 Excellent Abstracts and received the Investigators Awards at the conference.■■2022■■
Improved Sendai viral system for reprogramming to naive pluripotency
Kunitomi A , Hirohata R , Arreola V , Osawa M ,Kato T , Nomura M , Kawaguchi J , Hara H , Kusano K , Takashima Y , Takahashi K , Fukuda K , Takasu N , Yamanaka S iScience:doi.org/10.1016/j.isci.2022.105052
Induced hepatic stem cells are suitable for human hepatocyte production
Nakashima Y , Miyagi-Shiohira C , Saitoh I , Watanabe M , Matsushita M , Tsukahara M , Noguchi H
iScience:doi.org/10.1016/j.isci.2022.105052
Semi-3D cultures using Laminin 221 as a coating material for human induced pluripotent stem cells
Nakashima Y , Yoshida S , Tsukahara M
Regenerative Biomaterials :doi.org/10.1093/rb/rbac060
Adhesion Characteristics of Human Pancreatic Islets, Duct Epithelial Cells, and Acinar Cells to a Polymer Scaffold
Nakashima Y , Iguchi H, Takakura K , Nakamura Y , Izumi K , Koba N , Haneda S , Tsukahara M
Cell Transplantation : doi.org/10.1177/09636897221120500
Laminin-511 Activates the Human Induced Pluripotent Stem Cell Survival via α6β1 Integrin-Fyn-RhoA-ROCK Signaling
Nakashima Y , Tsukahara M
Stem Cells and Development : doi.org/10.1089/scd.2022.0010
Generation of hypoimmunogenic induced pluripotent stem cells by CRISPR-Cas9 system and detailed evaluation for clinical application
Kitano Y, Nishimura S, Kato T, Ueda A, Takigawa K, Umekage M, Nomura M, Kawakami A, Ogawa H, Huaigeng X , Hotta A , Takasu N, Tsukahara M*
Molecular Therapy - Methods & Clinical Development: doi.org/10.1016/j.omtm.2022.05.010
A chemically-defined plastic scaffold for the xeno-free production of human pluripotent stem cells
Shimizu E, Iguchi H, Le M N T, Nakamura Y, Kobayashi D, Arai Y, Takakura K, Benno S, Yoshida N, Tsukahara M, Haneda S, Hasegawa K
Scientific Reports volume 12: 2516 doi.org/10.1038/s41598-022-06356-8 (2022)
■■2021■■
Grafting of iPS cell-derived tenocytes promotes motor function recovery after Achilles tendon rupture
Nakajima T, Nakahata A, Yamada N, Yoshizawa K, Kato TM, Iwasaki M, Zhao C, Kuroki H, Ikeya M
Nature Communications 12: 5012 doi: 10.1038/s41467-021-25328-6 (2021)
Transplantation of human autologous synovial mesenchymal stem cells with trisomy 7 into the knee joint and 5 years of follow-up
Mizuno M, Endo K, Katano H, Amano N, Nomura M, Yoshinori Hasegawa, Nobutake Ozeki, Hideyuki Koga, Takasu N, Osamu Ohara, Tomohiro Morio, Ichiro Sekiya
Stem Cell Research Volume 50 102033 doi :10.1016/j.scr.2020.102033 (2021)
CiRA iPSC seed stocks (CiRA's iPSC Stock Project)
Hanatani T, Takasu N
Stem Cell Research Volume 50 102033 doi :10.1016/j.scr.2020.102033 (2021)
■■2020■■
Pre-clinical study of induced pluripotent stem cell-derived dopaminergic progenitor cells for Parkinson's disease
Doi D, Magotani H, Kikuchi T, Ikeda M, Hiramatsu S, Yoshida K, Amano N, Nomura M, Umekage M, Morizane A, Takahashi J
Nat Commun 11: 3369 doi: 10.1038/s41467-020-17165-w (2020)
HLA-Matched Allogeneic iPS Cells-Derived RPE Transplantation for Macular Degeneration
Sugita S, Mandai M, Hirami Y, Takagi S, Maeda T, Fujihara M, Matsuzaki M, Yamamoto M, Iseki K, Hayashi N, Hono A, Fujino S, Koide N, Sakai N, Shibata Y, Terada M, Nishida M, Dohi H, Nomura M, Amano N, Sakaguchi H, Hara C, Maruyama K, Daimon T, Igeta M, Oda T, Shirono U, Tozaki M, Totani K, Sugiyama S, Nishida K, Kurimoto Y, Takahashi M
J Clin Med 9(7): 2217 doi: 10.3390/jcm9072217 (2020)
Non-clinical efficacy, safety and stable clinical cell processing of induced pluripotent stem cell-derived anti-glypican-3 chimeric antigen receptor-expressing natural killer/innate lymphoid cells
Ueda T , Kumagai A , Iriguchi S , Yasui Y , Miyasaka T , Nakagoshi K , Nakane K , Saito K , Takahashi M , Sasaki A , Yoshida S , Takasu N , Seno H , Uemura Y , Tamada K , Nakatsura T , Kaneko S
PMID: 32133731 doi: 10.1111/cas.14374
■■2019■■
Overview: an iPS cell stock at CiRA
Umekage M, Sato Y, Takasu N
Inflamm Regener 39: 17 doi: 10.1186/s41232-019-0106-0 (2019)
Targeted Disruption of HLA Genes via CRISPR-Cas9 Generates iPSCs with Enhanced Immune Compatibility
Xu H, Wang B, Ono M, Kagita A, Fujii K, Sasakawa N, Ueda T, Gee P, Nishikawa M, Nomura M, Kitaoka F, Takahashi T, Okita K, Yoshida Y, Kaneko S, Hotta A
Cell Stem Cell 24(4):566-578.e7 doi: 10.1016/j.stem (2019)
■■2018■■
Quality control guidelines for clinical-grade human induced pluripotent stem cell lines
Sullivan S, Stacey GN, Akazawa C, Aoyama N, Baptista R, Bedford P, Griscelli AB, Chandra A, Elwood N, Girard M, Kawamata S, Hanatani T, Latsis T, Lin S, Ludwig TE, Malygina T, Mack A, Mountford JC, Noggle S, Pereira L, Price J, Sheldon M, Srivastava A, Stachelscheid H, Velayudhan SR, Ward NJ, Turner ML, Barry J, Song J.
Regen Med 13:859 doi: 10.2217/rme-2018-0095 (2018)
Report of the international conference on manufacturing and testing of pluripotent stem cells
Abbot S, Agbanyo F, Ahlfors JE, Baghbaderani BA, Bartido S, Bharti K, Burke C, Carlsson B, Cavagnaro J, Creasey A, DiGiusto D, Francissen K, Gaffney A, Goldring C, Gorba T, Griffiths E, Hanatani T, Hayakawa T, Heki T, Hoogendoorn K, Kawamata S, Kimura H, Kirkeby A, Knezevic I, Lebkowski J, Lin S, Lin-Gibson S, Lubiniecki A, O'Shea O, Pera M, Petricciani J, Pigeau G, Ratcliffe A, Sato Y, Schumann GG, Shingleton W, Stacey Chair G, Sullivan S, Svendsen CN, Trouvin JH, Vandeputte J, Yuan BZ, Zoon K.
Biologicals 56:67 doi: 10.1016/j.biologicals.2018.08.004 (2018)
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